There are two main goals of the HCA Standards and Technology Working Group (STWG):

  • To bring together people and their institutes to compare and disseminate existing methods,
  • To ensure that new techniques are developed and adopted. This is achieved by working with academics and technology companies that are eager to help the HCA and to learn from its collective expertise and experiences.

Co-chaired by Holger HeynOrit Rozenblatt-Rosen and Xiaowei Zhuang, the STWG meets once a month to discuss topical Standards and Technology issues for the HCA.

To assist the work of the STWG, a Seminar focussing on Technology, took place on March 10th 2022.

Presentations from members of the STWG

Orit Rozenblatt-Rosen (24 September 2020)

HCA Latin America Framework meeting

Holger Heyn (23-24 May 2019)

HCA Asia Meeting, Tokyo

Holger Heyn and Xiaowei Zhuang (01-02 November 2018)

HCA General Meeting, Boston

HCA branded Benchmarking publications

Building a high-quality Human Cell Atlas

Rozenblatt-Rosen O, Shin JW, Rood JE, Hupalowska A, Human Cell Atlas Standards and Technology Working Group, Regev A, Heyn H.

Nature Biotechnology 2021, 39(2):149-153.


Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

Ding J; Adiconis X; Simmons SK; Kowalczyk MS; Hession CC; Marjanovic ND; Hughes TK; Wadsworth MH; Burks T; Nguyen LT et al

Nature Biotechnology 2020, 38;6


Benchmarking single-cell RNA-sequencing protocols for cell atlas projects

Mereu, Elisabetta; Lafzi, Atefeh; Moutinho, Catia; Ziegenhain, Christoph; McCarthy, Davis J.; Álvarez-Varela, Adrián; Batlle, Eduard; Sagar; Grün, Dominic; Lau, Julia al

Nature Biotechnology 2020, 38;6;747-755


Sampling artifacts in single-cell genomics cohort studies

Massoni-Badosa R, Iacono G, Moutinho C, Kulis M, Palau N, Marchese D, Rodríguez-Ubreva J, Ballestar E, Rodriguez-Esteban G, Marsal S, Aymerich M, Colomer D, Campo E, Julià A, Martín-Subero JI, Heyn H.

Genome Biology 2020, 21(1):112

Online resources

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