Reproduction Biological Network

Additional information about this network, including datasets and any atlases assembled so far, can be found on our Data Portal.
Visit the HCA Data Portal

The reproductive system is the system of organs involved in producing offspring. Alterations of the physiological functions of the reproductive system can result in diseases such as infertility or cancer.

Immunofluorescence staining outlining different structures of ciliated cells in adult human fallopian tube. Image credit: Cecilia Lindskog lab, Uppsala University, Human Protein Atlas, Sweden.

The Reproductive Biological Network of the Human Cell Atlas aims to generate a detailed, dynamic map of the cells forming reproductive tissues across the lifespan. To do so, we are combining single-cell genomics with spatial transcriptomics and proteomics tools to disentangle tissue organization and cell signaling within the tissue compartments. This detailed study of the reproductive tissues will be critical for understanding many under-studied reproductive disorders, as well as cancer. Furthermore, the single-cell multi-omics roadmap for reproductive tissues will be used as a blueprint for the improvement and development of new in vitro models to recapitulate cell behavior in physiological and pathological conditions.

Network Coordinators: